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Fight or Flight? : Evolutionary Medical Structure of Immunology, its Philosophical Implications |
Fight or Flight ? : Evolutionary Medical Structure of Immunology, its Philosophical Implications Jongduck Choi The aim of my paper is to interpret diverse relations between host and parasite by integrating evolutionary medicine and immunology. An immunological thinking could be reconstructed by specific metaphors such as ‘fighting’, ‘killing’, ‘protection’, ‘immune evasion’, ‘seizure’, or ‘coexistence’. The response of infectious microbes against the host’s attack, where the strained relations between microbes and immune system are activating, directs toward for their own surviving and reproducing through the incessant mutations of microbes as like bacteria and virus do. I will hereby show that the very philosophical category of evolutionary immunology might be formed through my thesis. It is to be unfolded as below. Firstly, I will arrange the evolutionary etiology. Secondly, I show that infectious diseases could be explained well by using the immunological metaphors. Thirdly, the relation between an evolutionary mutation of parasite and immunological activation of host will be illuminated by the concrete cases such as antibiotic, vaccine, and AZT. Fourthly, it will be highlighted that the evolution speed of mutation’s rate for infectious virus exceeds the capacity of horotelic human’s immunity. Lastly, it will be recognized that antibiotic biomedicine or antiviral medicine ultimately do not succeed in doing their role. So I suggest the necessity of medical preparation with concept of coalescence between human and microbes. My conclusion is that medical preparation of that kind of coalescence can be found in the integration of evolutionary medicine and cell based immunology. Bergstrom, C. T. & Feldgarden, M. (2008), “The Ecology and Evolution of Antibiotic-Resistant Bacteria”, in Stearns, S. C. & Koella, J. C. (eds.) Evolution in health and disease, 2nd ed., Oxford, UK: Oxford University Press. Boyer, P., Sarafianos, S, Arnold, E. & Hughes, S. (2001), “Selective Excision of AZTMP by Drug-Resistant Human Immunodeficiency Virus Reverse Transcriptase”, Journal of virology 75(10): pp. 4832-42. Campisi, J. (2003), “Cancer and Ageing: Rival Demons?” Nature Reviews Cancer 3: pp. 339-49. Cournoyea, M. (2013), “Ancestral Assumptions and the Clinical Uncertainty to Evolutionary Medicine”, Perspectives in Biology and Medicine, 56(1): pp. 36-52. Cann, A. (2005), Principles of Molecular Virology, 4th ed, Academic Press. Diacovich, L. & Gorvel, J. P. (2010), “Bacterial Manipulation of Innate Immunity to Promote Infection”, Nature Reviews Microbiology 8: pp. 117-28. Eaton, B. & Stanley B. (2003), “An Evolutionary Perspective on Human Physical Activity: Implications for Health”, Comparative Biochemistry and Physiology Part A 136: pp. 153-59. Eaton, S., Cordain, L. & Lindeberg, S. (2002), “Evolutionary Health Promotion: a Consideration of Common Counter Arguments”, Preventive Medicine: An International Journal Devoted to Practice and Theory 34(2): pp. 119-23. Ewald P. W. (1980), “Evolutionary Biology and the Treatment of Signs and Symptoms of Infectious Disease”, Journal of Theoretical Biology 86: pp. 169-76. (1999), “Evolutionary Control of HIV and Other Sexually Transmitted Viruses“, in Trevathan, W. et al. (eds.) Evolutionary Medicine, New York: Oxford University Press. (1993), Evolution of Infectious Disease, New York: Oxford University Press. Gkuckmann, P. Beedle, A. & Hanson, M. (2009), Principles of Evolutionary Medicine, Oxford. Greaves, M. (2007), “Darwinian Medicine: a Case for Cancer”, Nature Reviews Cancer 7(3): pp. 213-21. Hajishengallis, G. & Lambris, J. D. (2011), “Microbial Manipulation of Receptor Cross Talk in Innate Immunity”, Nature Reviews Immunology 11(3): pp. 187-200. Hanson, N. & Lanning, D. (2008), “Microbial Induction of B and T Cell Areas in Rabbit Appendix”, Developmental & Comparative Immunology 32(8): pp. 980-91. Herron, J. & Freeman, S. (2014), Evolutionary Analysis, 5th ed, Pearson. Hogg, R., Montaner, J., Wood, E. et al. (2006), “The Case for Expanding Access to Highly Active Antiretroviral Therapy to Curb the Growth of the HIV Epidemic”, The Lancet 368(9534): pp. 531-36. Kato, S. et al. (2015), “Global Brain Dynamics Embed the Another Command Sequence of Caenorhabditis Elegans”, Cell 163(3): pp. 656-69. Kweon, M. et al. (2016), “Enteric Viruses Ameliorate Gut Inflammation Via Toll-Like Receptor 3 and Toll-Like Receptor 7-Mediated Interferon-β Production”, Immunity 44(4): pp. 889-900. Lachmann, P., Lachmann, P. J. & Oldstone, M. B. A. (2006), Microbial Subversion of Immunity, Norfolk, UK: Caister Academic Press. Larder, B. A., Darby, G. & Richman, D. D. (1989), “HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy” Science 243(4899): pp. 1731-35. Lazano, G. A. (2010), “Evolutionary Explanations in Medicine: How Do They Differ and How to Benefit from Them”, Medical Hypotheses 74(4): pp. 746-49. Levin B. R. & Anderson R. M. (1999), “The Population Biology of Anti-Infective Chemotherapy and the Evolution of Resistance: More Questions Than Answers”, in Stearns, S. (ed.), Evolution in Health and Disease, New York: Oxford University Press. Moxon, R. R., Bayliss, C. C. & Hood, D. D. (2005), “Bacterial Contingency Loci: the Role of Simple Sequence DNA Repeats in Bacterial Adaptation”, Annu. Rev. Genet. 40: pp. 307-33. Nachman M. W. & Crowell S. L. (2000), “Estimate of the Mutation Rate Per Nucleotide in Humans”, Genetics 156(1): pp. 297-304. Nesse, R. M. & Williams, G. C. (1994), Why We Get Sick: the New Science of Darwinian Medicine, Time Books. Nesse, R. M. (2005), “Maladaptation and Natural Selection”, Quaterly Review of Biology (1): pp. 62-71. ___________ (2012), “Evolution: a Basic Science for Medicine”, in Poiani, A. (ed.), Pragmatic Evolution: Applications of Evolutionary Theory, Cambridge Univ. Press. Perez-Caballero, D., Zang, T. et al. (2009), “Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells”, Cell 139(3): pp. 499-511. Price, D. A., Goulder, P. J. et al. (1997), “Positive Selection of HIV-1 Cyto-Toxic T Lymphocyte Escape Variants During Primary Infection”, Proceedings of the National Academy of Sciences USA 94(5): pp. 1890-95. Purrmann, J. et al. (1992), “Association of Crohn’s Disease and Multiple Sclerosis: Is There a Common Background?”, Journal of Clinical Gastroenterology, 14(1): pp. 43-46. Raberg, L., Graham, A. L. & Read, A. F. (2009), “Decomposing Health: Tolerance and Resistance to Parasites in Animals”, Philosophical Transactions of the Royal Society of London B: Biological Sciences 364(1513): pp. 37-49. Read, A. F., Day, T. & Huijben, S. (2011), “The Evolution of Drug Resistance and the Curious Oxthodoxy of Aggressive Chemotheraphy”, Proceedings of the National Academy of Sciences, 108(Supplement 2): pp. 10871-10877. Sacks O. (2010), “Face-Blind: Why Are Some of Us Terrible at Recognizing Faces?”, New Yorker(Aug. 30, 2010): pp. 36-43. Sauter, D., Schindler, M. et al. (2009), “Tetherin-Driven Adaptation of Vpu and Nef Function and the Evolution of Pandemic and Non Pandemic HIV-1 Strains”, Cell Host Microbe 6(5): pp. 409-21. Schneider, D. S. & Ayres, J. S. (2008), “Two Ways to Survive Infection: What Resistance and Tolerance Can Teach Us About Treating Infectious Diseases”, Nature Reviews Immunology 8(11): pp. 889-895 . Shankarappa, R. et al. (1999), “Consistent Viral Evolutionary Changes Associated With the Progression of Human Immunodeficiency Virus Type 1 Infection”, Journal of Virology 73(12): 10489-502. St Clair, W. H. et al. (1991), “Influence of Proliferation on DNA Repair Rates in Liver”, Experimental Cell Research, 197(2): pp. 323-25. Stearns, S. C. (2012), “Evolutionary Medicine: Its Scope, Interest and Potential”, Proceeding of the Royal British Society 279: pp. 4305-21. Strachan, D. P. (2000). “Family Size, Infection and Atopy: the First Decade of the ‘Hygiene Hypothesis’”, Thorax 55(1): pp. 2-10. Varki, A. (2012), “Nothing in Medicine Makes Sense, Except in the Light of Evolution”, Journal of Molecular Medicine 90(5): pp. 481-94. Xue, Y. et al. (2009), “Human Y Chromosome Base-Substitution Mutation Rate Measured by Direct Sequencing in a Deep-Rooting Pedigree”, Current Biology (17): pp. 1453-57. Yap, M. W., Nisole, S. & Stoye, J. P. (2005), “A Single Amino Acid Change in the SPRY Domain of Human TRIMa Leads to HIV-1 Restriction”, Current Biology 15(1): pp. 73-78. Yazdanbakhsh, M., Kremsner, P. G. & Van Ree, R. (2002), “Allergy, Parasites and the Hygine Hypothesis”, Science 296(5567): pp. 490-94. Zampieri, F. (2009), “Origin and History of Darwinian Medicine”, Human Mente 9: pp. 13-38. |